Never miss an update from Fundació URV
Create your free account to connect with Fundació URV and thousands of other innovative organizations and professionals worldwide
Gallic Acid is a naturally occurring phenolic compound that is widely distributed throughout the plant kingdom. Different studies have demonstrated the strong antioxidant, anti-inflammatory, anti-mutagenic and anticancer properties of GA, and daily intake may reduce the risk of diseases and bring health benefits. More recently, Gallic Acid has also been studied for its beneficial effects on cardiovascular diseases. It inhibits dyslipidemia, hepatosteatosis and oxidative stress in high-fat diet fed rats, protects the myocardium against isoproterenol-induced oxidative stress in rats, ameliorates the heart-function defects of myocardial dysfunction associated with streptozotocin-induced type-1 diabetic rats and exhibits anti-hyperglycemic and lipid-lowering properties in high-fat diet mice.
Gallic Acid is commonly used as antioxidant by the food industry. However, until now, it is not known that the gallic acid could block the renin-angiotensin-aldosterone system (RAAS), which is the innovative aspect discover for the Nutrigenomic Group for the Gallic Acid. The inhibition of the RAAS by Gallic Acid is considered to be of special relevance because RAAS overactivity is currently associated with not only hypertension but also vascular inflammation, the development of atherosclerosis, left ventricular hypertrophy, nephrosclerosis and cardiovascular events. This discovery has a big importance because it opens a wide field of use for this compound in the food, nutraceutical or pharmaceutical industry.
Description of the technology
A new function for the Gallic Acid and its pharmaceutically acceptable salts has been reported by the Nutrigenomics Research Group at the Biochemistry and Biotechnology Department of the Rovira i Virgili University. This new function is that the gallic acid blocks the renin-angiotensin-aldosterone system. For this reason, these compounds can be used in the preparation of a medicament for the treatment of diseases produced by hyperactivation of the renin-angiotensin-aldosterone system, such as,cardiovascular diseases, cerebrovascular diseases, kidney diseases or diabetes. The invention also relates to their use in the pharmaceutical, dietetic and food industry.
Specifications
Gallic Acid is a water soluble phenolic acid also known as 3,4,5-trihydroxybenzoic acid. It is present in gallnuts, sumac, witch hazel, tea leaves, oak bark, and other plants. This acid is found both free and as part of hydrolysable tannins. Gallic Acid esters, such as tannins, catechin gallates and aliphatic gallates are potent antioxidants in vitro. However, gallic acid itself also appears to have antioxidant, anticarcinogenic and antiangiogenic activity in vitro. However, the use of gallic acid and its salts to block the renin-angiotensin-aldosterone system has never been reported. Nutrigenomic research group has reported that Gallic Acid decreased blood pressure in hypertensive rats.
Main advantages of its use
Applications
The Technology Transfer and Innovation Center (CTTi) meets from the University environment the technological needs and services generated by the productive sectors and administration, through the management of Transfer of Technology and Knowledge, the Intellectual and Intellectual Property management, Technology Watch, Entrepreneurship, and Technology Infrastructures Offer (business incubator).
Create your free account to connect with Fundació URV and thousands of other innovative organizations and professionals worldwide
Send a request for information
to Fundació URV
Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.
Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support